Fig. 18, 93W5540, Ovary, Corpus Luteum, H&E
The granulosa lutein cells (GLC) contain a large spherical nucleus and a
large amount of cytoplasm. Theca lutein cells (TLC) also contain a
spherical nucleus, but the cells are smaller than the granulosa lutein cells.
Thus, when identifying the two cell types, aside from location, note that
the nuclei of adjacent theca lutein cells generally appear to be closer to
each other than nuclei of adjacent granulosa lutein cells. The connective
tissue (CT) and small blood vessels that invaded the mass of corpus
luteum can be identified as the flattened and elongated components.
If pregnancy occurs, the corpus luteum remains functional; if pregnancy
does not occur, the corpus luteum regresses after having reached a point
of peak development, roughly 2 weeks after ovulation. The regressing
cellular components of the corpus luteum are replaced by fibrous
connective tissue, and the structure is then called a corpus albicans.