Fig. 14, 93W7260, Ovary Mature, Human, H&E
When a primordial follicle (PF) begins changes leading to the
formation of a mature follicle, the layer of squamous follicular cells
(F) becomes cuboidal . In addition, the follicular cells proliferate
and become multilayered. A follicle undergoing these early
changes is called a primary follicle (PRF). Thus, an early primary
follicle may still be unilaminar but it is surrounded by cuboidal
cells, and this distinguishes it from the more numerous unilaminar
primordial follicles that are surrounded by squamous cells. The
nucleus (N) of the oocyte is typically large, but the oocyte itself is
so large that the nucleus is often not included in the plane of
section (X). The innermost layer of follicular cells is adjacent to a
thick eosinophilic layer of extracellular homogeneous material
called the zona pellucida (ZP).