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block14_27.jpg - Fig. 14, 93W7260, Ovary Mature, Human, H&EWhen a primordial follicle (PF) begins changes leading to the  formation of a mature follicle, the layer of squamous follicular cells  (F) becomes cuboidal . In addition, the follicular cells proliferate  and become multilayered. A follicle undergoing these early  changes is called a primary follicle (PRF). Thus, an early primary  follicle may still be unilaminar but it is surrounded by cuboidal  cells, and this distinguishes it from the more numerous unilaminar  primordial follicles that are surrounded by squamous cells. The  nucleus (N) of the oocyte is typically large, but the oocyte itself is  so large that the nucleus is often not included in the plane of  section (X). The innermost layer of follicular cells is adjacent to a  thick eosinophilic layer of extracellular homogeneous material  called the zona pellucida (ZP).

Fig. 14, 93W7260, Ovary Mature, Human, H&E When a primordial follicle (PF) begins changes leading to the formation of a mature follicle, the layer of squamous follicular cells (F) becomes cuboidal . In addition, the follicular cells proliferate and become multilayered. A follicle undergoing these early changes is called a primary follicle (PRF). Thus, an early primary follicle may still be unilaminar but it is surrounded by cuboidal cells, and this distinguishes it from the more numerous unilaminar primordial follicles that are surrounded by squamous cells. The nucleus (N) of the oocyte is typically large, but the oocyte itself is so large that the nucleus is often not included in the plane of section (X). The innermost layer of follicular cells is adjacent to a thick eosinophilic layer of extracellular homogeneous material called the zona pellucida (ZP).
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